Embracing rather than rejecting variability in lab mice could improve test outcomes.
Using mutant mice to find treatments for devastating diseases such as Alzheimer’s has failed, but that could change by harnessing diversity in the animals, rather than stamping it out, according to authors of a review in the journal Science Translational Medicine.
Neuroscientists Elizabeth Fisher, from University College London, and David Bannerman, from the University of Oxford, both in the UK, pull no punches in calling out the status quo.
“Despite the hundreds of mouse models of human neurodegenerative disease, we still have no cure for any major form of neurodegeneration,” they say.
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